Mass Spectrometry for Proteome Characterization

Exploring different mass spectrometry methods and their applications in clinical proteomics

Clinical Lab Manager

Clinical proteomics methods are aimed at identifying proteins involved in pathological processes, identifying predictive and prognostic biomarkers and potential targets for new therapeutics. Proteome characterization is often achieved with liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), electrospray ionization (LC-ESI-MS), and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF-MS). Here we explore the different methods and their applications. 

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