Mutations in the RIPK1 gene responsible for CRIA syndrome

The phase II trial found that over 80 percent of men with prostate cancer whose tumors had mutations in the BRCA genes responded well to treatment with the targeted drug olaparib

Researchers have found a previously unappreciated hematopoietic wave taking place in the bone marrow of late fetuses and young adults and producing HSCs from resident hemogenic endothelial cells of somite origin

Researchers have developed a new genomic method, named CUTseq, which can assess the amount and type of CNAs in many different parts of the same tumor, at a much lower cost than existing technologies 

The environmental and genetic factors underlying IPF are largely unknown, and there are no effective approaches available to reverse development of the disease

The new variant reduced unintended changes in DNA compared to its wildtype, suggesting it could play a role in gene therapies that require high precision

A multifaceted approach will be needed to track and control the spread of extensively drug-resistant Salmonella, including further microbiological and genomic surveillance

Leaders in BRCA research say screening recommendations from the US Preventive Services Task Force are a positive step forward, but testing of individuals with the highest risk must improve

Researchers at Baylor College of Medicine have conducted the most comprehensive study of TP53 mutations to better understand the processes leading to the inactivation of this important gene