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MRI, Clear Cell Likelihood Score Correlate with Renal Mass Growth Rate

Standardized non-invasive clear cell likelihood score correlates with the growth rate of small renal masses

LEESBURG, VA, — According to the American Roentgen Ray Society's (ARRS) American Journal of Roentgenology (AJR), the standardized non-invasive clear cell likelihood score (ccLS)—derived from MRI—correlates with the growth rate of small renal masses (cT1a, <4 cm) and may help guide personalized management.

Extracted from clinical reports, "the ccLS scores the likelihood that the small renal mass represents clear cell renal cell carcinoma, from one (very unlikely) to five (very likely)," explained corresponding author Ivan Pedrosa from the University of Texas Southwestern Medical Center at Dallas. "Small renal masses with lower ccLS may be considered for active surveillance, whereas small renal masses with higher ccLS may warrant earlier intervention."

Pedrosa and colleagues' retrospective study included consecutive small renal masses assigned a ccLS on clinical MRI examinations performed between June 2016 and November 2019 at an academic tertiary-care medical center or its affiliated safety net hospital system. Tumor size measurements were extracted from available prior and follow-up cross-sectional imaging examinations, through June 2020.

Among 389 small renal masses in 339 patients (198 men, 141 women; median age, 65 years) on active surveillance that were assigned a ccLS on clinical MRI examinations, those with ccLS four–five grew significantly faster (nine percent diameter, 29 percent volume yearly) than those with ccLS one–two (five percent diameter, p<.001; 16 percent volume, p<.001) or ccLS three (four percent diameter, p<.001; 15 percent volume, p<.001).

Noting that the lack of validated imaging markers to characterize biologic aggressiveness of small renal masses hinders medical decision making among available initial management strategies, "growth is associated with ccLS in small renal masses," the authors of this AJR article reiterated, "with higher ccLS correlating with faster growth."

- This press release was originally published on the American Roentgen Ray Society website